Skip To Main Content

This website is not intended to be a substitute for medical advice. Please refer to the Patient information leaflet and the Patient Guide for full safety information. You may have received these items from your doctor already.

The Tzield (teplizumab)
treatment process

Information for before, during, and after your Tzield treatment

How is Tzield given?

Tzield is administered by a doctor or nurse through a needle placed in a vein in your arm. This process is called an infusion.1

You will be given an infusion every day for 14 days and each infusion will last for 30 minutes.1

It’s normal to feel nervous about starting a new treatment. Find out more about the Tzield infusion process below so you can feel prepared for your infusions.

What to bring with you

Each infusion lasts for at least 30 minutes,1 so it’s a good idea to bring something to keep you occupied.

You might want to bring:

  • Headphones
  • A book
  • Something to write/draw with

Make sure you wear comfortable clothes and bring an extra layer in case you get cold.

Getting to the infusion centre

Tzield is not expected to affect your ability to drive and use machines. However, if you feel tired, do not drive or use machines before discussing it with your doctor or nurse.1

Plan your route to the infusion centre and research where to park before you set off.

Allow extra time for travel so you can relax and not feel rushed before treatment.

Medicines given while you have Tzield1

Before you receive your first five doses of Tzield, your doctor or nurse will give you some extra medicines to help prevent some potential side effects.

These may include:

  • Ibuprofen or naproxen (or other medicines for fever, like paracetamol)
  • An antihistamine to reduce allergic reactions
  • An anti-sickness (anti-nausea) medicine

These medicines may help reduce symptoms of cytokine release syndrome (CRS).

Blood tests

Before starting Tzield, you will have a blood test to measure the cells in your blood (a complete blood count) and baseline liver function.

How long will I be on treatment?1

You will be given a Tzield infusion once a day for 14 days. Each infusion will last at least 30 minutes.

It’s a good idea to allow some time before and after the treatment so that your doctor or nurse can prepare the infusion and monitor you afterward.

If one of your infusions is missed, your doctor or nurse will continue the treatment on the next scheduled day to complete the 14-day course. You won’t receive two infusions on the same day.

Download your 14-day treatment planner here

Support with needle phobia2

Your infusions will involve needles. If you, or the person you care for, are afraid or worried about needles, there are a few things you can do to help overcome your fear. Find out more on our Resources & support page.

When you have finished the Tzield infusions, your doctor will discuss a care plan with you for monitoring blood sugar.

Why is it important to monitor your blood sugar after Tzield?

While Tzield helps to delay the progression from Stage 2 autoimmune Type 1 diabetes (T1D) to Stage 3, it cannot be fully prevented. Monitoring blood sugar levels helps to make sure you are diagnosed with Stage 3 T1D at the right time and this ongoing monitoring should be discussed with you by your doctor.3

There are a number of signs and symptoms that may indicate your T1D is progressing.4

Find out more

You may be interested to find out…

The symptoms of Stage 3 T1D

Read more

What is DKA?

Read more

What resources and support are available to me?

Read more

Tzield is a medicine used to delay the start of Stage 3 Type 1 diabetes. This condition happens when the body cannot make enough insulin on its own and may need insulin injections. This medicine is used in adults and children aged 8 years and older who have Stage 2 Type 1 diabetes.1

If you have any questions on how Tzield works or about your treatment with Tzield, ask your doctor.

This website is not intended to be a substitute for medical advice. Please refer to the Patient information leaflet and the Patient Guide for full safety information. You may have received these items from your doctor already.

The contents of this website have been developed and funded by Sanofi.

 

References:

  1. TZIELD® (teplizumab) UK Patient Information Leaflet. Accessed: November 2025.
  2. NHS. Needle phobia and overcoming your fear. Available at: https://www.guysandstthomas.nhs.uk/health-information/needle-phobia-and-overcoming-your-fear. Accessed: November 2025.
  3. TZIELD® (teplizumab) UK Summary of Product Characteristics. Accessed: November 2025.
  4. Diabetes UK. Type 1 diabetes symptoms. Available at: https://www.diabetes.org.uk/about-diabetes/type-1-diabetes/symptoms. Accessed: November 2025.

Reporting side effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple app Store.

Alternatively, you can report side effects to Sanofi on Tel: 0800 0902 314 or send via email to UK-drugsafety@sanofi.com. By reporting side effects, you can help provide more information on the safety of this medicine.

▼This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side effects that you may get. See www.mhra.gov.uk/yellowcard for how to report side effects.

© 2025 Sanofi. All rights reserved. MAT-XU-2502708 (V1.0) | November 2025