Preparing for Stage 3 autoimmune Type 1 diabetes (T1D)
Learn about Stage 3 T1D
Preparing for Stage 3 T1D
Tzield is a medicine used to delay the start of Stage 3 T1D. This condition happens when the body cannot make enough insulin on its own and may need insulin injections.1
What are the symptoms of Stage 3 T1D?2
The symptoms for Stage 3 T1D are similar at any age, and you can remember the key symptoms as the 4Ts:
Toilet
Going for a wee more often (especially at night)
Thirsty
Being constantly thirsty and not being able to quench it
Tired
Feeling incredibly tired and lacking energy
Thinner
Losing weight without trying to, or looking thinner than usual
The 4Ts are the most common symptoms of Stage 3 T1D, but there are other symptoms that you can look out for:
- Genital itching or thrush
- Cuts and wounds that take a long time to heal
- Blurry eyesight
Talk to your doctor if you
experience any symptoms of
Stage 3 T1D
What might happen if Stage 3 T1D is left undiagnosed?2,3
If insulin levels fall too low, the body can’t function properly. Without insulin, your body starts to break down fat to use for energy, which releases harmful chemicals called ketones. When ketones build up, they make your blood acidic and make you feel poorly. This is called diabetic ketoacidosis (DKA).
DKA is a serious and life-threatening condition where you can become very ill, really quickly. Learn the symptoms of DKA so you can get help quickly.
Let your doctor or nurse know as soon as possible if you, or the person you care for, experience any of the following symptoms of DKA:
Tzield is a medicine used to delay the start of Stage 3 Type 1 diabetes. This condition happens when the body cannot make enough insulin on its own and may need insulin injections. This medicine is used in adults and children aged 8 years and older who have Stage 2 Type 1 diabetes.1
If you have any questions on how Tzield works or about your treatment with Tzield, ask your doctor.
This website is not intended to be a substitute for medical advice. Please refer to the Patient information leaflet and the Patient Guide for full safety information. You may have received these items from your doctor already.
The contents of this website have been developed and funded by Sanofi.
References:
- TZIELD® (teplizumab) UK Patient Information Leaflet. Accessed: November 2025.
- Diabetes UK. Type 1 diabetes symptoms. Available at: https://www.diabetes.org.uk/about-diabetes/type-1-diabetes/symptoms. Accessed: November 2025.
- Diabetes UK. What is DKA (diabetic ketoacidosis)? Available at: https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/complications/diabetic-ketoacidosis. Accessed: November 2025.
Reporting side effects
If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple app Store.
Alternatively, you can report side effects to Sanofi on Tel: 0800 0902 314 or send via email to UK-drugsafety@sanofi.com. By reporting side effects, you can help provide more information on the safety of this medicine.
▼This medicine is subject to additional monitoring. This will allow quick identification of new safety information. You can help by reporting any side effects that you may get. See www.mhra.gov.uk/yellowcard for how to report side effects.
© 2025 Sanofi. All rights reserved. MAT-XU-2502709 (V1.0) | November 2025
Welcome to Tzield
Welcome to Tzield
This website and its contents have been developed by Sanofi for patients in the United Kingdom who have been prescribed Tzield.
In order to proceed into the website, please confirm that you are, or you care for, a patient in the United Kingdom prescribed Tzield by clicking the confirmation button below.
MAT-XU-2503330 (V1.0) - Date of preparation: November 2025