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How does Tzield (teplizumab) work?

Tzield is a medicine that contains the active substance teplizumab. It belongs to a group of medicines called ‘monoclonal antibodies'.1,2

Tzield is a protein that recognises and sticks to a target. The target is a substance called CD3 that is found on a type of white blood cell – called ‘T lymphocytes’.1,2

When Tzield sticks to T lymphocytes it can help to slow down the attack on beta cells.2,3

By slowing down the autoimmune attack on beta cells, your pancreas can keep producing insulin on its own for
a little longer.2,3

 

You may be interested to find out…

What are autoantibodies?

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What are the stages of T1D?

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How is Tzield
given?

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Tzield is a medicine used to delay the start of Stage 3 Type 1 diabetes. This condition happens when the body cannot make enough insulin on its own and may need insulin injections. This medicine is used in adults and children aged 8 years and older who have Stage 2 Type 1 diabetes.1

If you have any questions on how Tzield works or about your treatment with Tzield, ask your doctor.

This website is not intended to be a substitute for medical advice. Please refer to the Patient information leaflet and the Patient Guide for full safety information. You may have received these items from your doctor already.

 

References

  1. TZIELD® (teplizumab) UK Patient Information Leaflet. Accessed: November 2025.
  2. TZIELD® (teplizumab) UK Summary of Product Characteristics. Accessed: November 2025.
  3. Nagy G, Szekely TE, Somogyi A, et al. New therapeutic approaches for type 1 diabetes: Disease-modifying therapies. World J Diabetes. 2022; 13(10): 835–850. 

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